Glial Dysfunction Causes Age-Related Memory Impairment in Drosophila
نویسندگان
چکیده
منابع مشابه
Genetic Dissection of Age-related Memory Impairment in Drosophila
Age-related memory impairment (AMI) is an important phenotype of brain aging. Understanding the molecular mechanisms underlying AMI is important not only from a scientific viewpoint but also for the development of therapeutics that may eventually lead to developing drugs to combat memory loss. AMI has been generally considered to be an overall or nonspecifi c decay of memory processes that resu...
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Age-related memory impairment (AMI) is a critical and debilitating phenotype of brain aging, but its underlying molecular mechanisms are largely unknown. In Drosophila, AMI is highly correlated with PKA activity in the mushroom bodies, neural centers essential for forming associative olfactory memories. Heterozygous mutations in DC0 (DC0/+), which encodes the major catalytic subunit of PKA (PKA...
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ژورنال
عنوان ژورنال: Neuron
سال: 2014
ISSN: 0896-6273
DOI: 10.1016/j.neuron.2014.09.039